In this section
@article{Qureshi:2026:10.1016/j.newton.2025.100302,
author = {Qureshi, B and Poulton, J and Ouldridge, T},
doi = {10.1016/j.newton.2025.100302},
journal = {Newton},
title = {Thermodynamic limits on general far-from-equilibrium molecular templating networks},
url = {http://dx.doi.org/10.1016/j.newton.2025.100302},
volume = {2},
year = {2026}
}
TY - JOUR
AB - Cells maintain a highly specific, far-from-equilibrium population of RNA and protein molecules. They do so via complex reaction networks in which templates catalyse the assembly of desired products. We show that information transmission from templates to products in such networks is bounded by functions of the maximal difference in free-energy changes between assembly path-ways. Surprisingly, putative systems operating at the bounds do not have a high net flux around the network, as is typical in far-from-equilibrium systems and observed in biology. Instead, the upper bound on accuracy for a given network structure is achieved in “pseudo-equilibrium”. Here, each product is produced and degraded by time-reversed trajectories along a single (product-specific) pathway with negligible entropy production; product yields are determined by the free-energy changes along those pathways. The limit imposed by these free-energy changes induces a thermodynamic constraint on accuracy, even if a single templating process is arbitrarily kinetically selective.
AU - Qureshi,B
AU - Poulton,J
AU - Ouldridge,T
DO - 10.1016/j.newton.2025.100302
PY - 2026///
SN - 2950-6360
TI - Thermodynamic limits on general far-from-equilibrium molecular templating networks
T2 - Newton
UR - http://dx.doi.org/10.1016/j.newton.2025.100302
UR - https://www.sciencedirect.com/science/article/pii/S2950636025002944
VL - 2
ER -
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