In this section
@article{Bakhtawar:2025:10.1021/acs.nanolett.5c03063,
author = {Bakhtawar, S and Smith, F and Sengar, A and Guy-Bart, S and Goertz, J and Stevens, M and Ouldridge, T and Bae, W},
doi = {10.1021/acs.nanolett.5c03063},
journal = {Nano Letters},
pages = {13772--13779},
title = {Overcoming the speed limit of four-way DNA branch migration with bulges in toeholds},
url = {http://dx.doi.org/10.1021/acs.nanolett.5c03063},
volume = {25},
year = {2025}
}
TY - JOUR
AB - Dynamic DNA nanotechnology creates programmable reaction networks and nanodevices using DNA strands.The key reaction in dynamic DNA nanotechnology is the exchange of DNA strands between different molecular species, achieved through three-way and four-way strand exchange reactions. While both reactions have been widely used, the fourway exchange reaction has traditionally been slower and less efficient than the three-way reaction. In this paper, we describe a new mechanism to optimise the kinetics of the four-way strand exchange reaction by adding bulges to the toeholds of the four-way DNA complexes involved in the reaction. These bulges facilitate an alternative branch migration mechanism and destabilise the four-way DNA junction, increasing the four-way strand exchange rate by an order of magnitude. This advancement has the potential to expand the field of dynamic DNA nanotechnology by enabling efficient four-way strand exchange reactions for in-vivo applications.
AU - Bakhtawar,S
AU - Smith,F
AU - Sengar,A
AU - Guy-Bart,S
AU - Goertz,J
AU - Stevens,M
AU - Ouldridge,T
AU - Bae,W
DO - 10.1021/acs.nanolett.5c03063
EP - 13779
PY - 2025///
SN - 1530-6984
SP - 13772
TI - Overcoming the speed limit of four-way DNA branch migration with bulges in toeholds
T2 - Nano Letters
UR - http://dx.doi.org/10.1021/acs.nanolett.5c03063
UR - https://pubs.acs.org/doi/full/10.1021/acs.nanolett.5c03063
VL - 25
ER -
Join our mailing list for regular updates, news, events and opportunities