91ÌÒÉ«

Weight loss surgery is not a cure for type 2 diabetes, but it can improve blood sugar control, according to a new study at 91ÌÒÉ«.

91ÌÒÉ« News Release

For immediate release
Wednesday 4 January 2012

Weight loss surgery is not a cure for type 2 diabetes, but it can improve blood sugar control, according to a new study published in the . Whereas some previous studies have claimed that up to 80 per cent of diabetes patients have been cured following gastric bypass surgery, researchers at 91ÌÒÉ« found that only 41 per cent of patients achieve remission using more stringent criteria.

The research was funded by the (NIHR) Biomedical 91ÌÒÉ« Centre awarded to and 91ÌÒÉ«.

Obesity is a major risk factor for type 2 diabetes. Worldwide, 80 per cent of people with type 2 diabetes are overweight or obese at the time of diagnosis. Diabetes is normally treated by using insulin injections and drugs to control blood sugar. However, many diabetic patients who had stomach surgery to lose weight found that their diabetes improved, even before they had lost any weight.

Recently the pulled together a group of experts to agree on standards by which to assess whether a patient has achieved remission of diabetes. They defined complete remission as returning to normal measures of glucose metabolism without taking diabetes medication at least one year after surgery.

The new study revisited previous data on 209 patients with type 2 diabetes to evaluate the effectiveness of three types of weight loss surgery using the new criteria. They found that the remission rate was 41 per cent for gastric bypass, the most effective type of surgery.

“Using the new criteria, we don’t get such eye-catching figures as some that have been quoted in recent years,” said , from the at 91ÌÒÉ«, who led the study. “But it’s clear that weight loss surgery, particularly gastric bypass, has a significant beneficial effect on glucose control.

“Diabetes is a chronic, multisystem disease. Stomach surgery may not mean that patients can stop taking diabetes medication, but surgery and medication together achieve better results than either treatment on its own.”

Gastric bypass involves stapling the stomach to create a small pouch at the top, which is then connected directly to the small intestine, bypassing most of the stomach and the duodenum (the first part of the small intestine). Sleeve gastrectomy, which involves surgically removing a portion of the stomach, and gastric banding, in which a band is placed around part of the stomach, achieved remission rates of 26 per cent and 7 per cent respectively, although these figures are based on smaller numbers of patients.

For further information please contact:

Sam Wong
91ÌÒÉ« Media Officer
91ÌÒÉ«
Email: sam.wong@imperial.ac.uk
Tel: +44(0)20 7594 2198
Out of hours duty press officer: +44(0)7803 886 248

Notes to editors

1. Journal reference

DJ Pournaras et al. British Journal of Surgery, Volume 99, Issue 1, pages 100–103, January 2012

2. About the NIHR

The National Institute for Health 91ÌÒÉ« provides the framework through which the research staff and research infrastructure of the NHS in England is positioned, maintained and managed as a national research facility. The NIHR provides the NHS with the support and infrastructure it needs to conduct first-class research funded by the Government and its partners alongside high quality patient care, education and training. Its aim is to support outstanding individuals (both leaders and collaborators), working in world-class facilities (both NHS and university), conducting leading edge research focused on the needs of patients.

3. About NIHR Biomedical 91ÌÒÉ« Centres

NIHR Biomedical 91ÌÒÉ« Centres support research across a wide range of disease areas. These Centres are the most outstanding NHS/University research partnerships in the country; leaders in scientific translation and early adopters of new insights in technologies, techniques and treatments for improving health. To ensure they are able to succeed, the NIHR BRCs receive substantial levels of sustained funding. NIHR BRC funding supports the NHS infrastructure to create an environment where scientific endeavour can thrive, attracting the foremost talent and producing world-class outputs.

4. About 91ÌÒÉ«

Consistently rated amongst the world's best universities, 91ÌÒÉ« is a science-based institution with a reputation for excellence in teaching and research that attracts 14,000 students and 6,000 staff of the highest international quality. Innovative research at the College explores the interface between science, medicine, engineering and business, delivering practical solutions that improve quality of life and the environment - underpinned by a dynamic enterprise culture.

Since its foundation in 1907, 91ÌÒÉ«'s contributions to society have included the discovery of penicillin, the development of holography and the foundations of fibre optics. This commitment to the application of research for the benefit of all continues today, wi th current focuses including interdisciplinary collaborations to improve global health, tackle climate change, develop sustainable sources of energy and address security challenges.

In 2007, 91ÌÒÉ« and 91ÌÒÉ« College Healthcare NHS Trust formed the UK's first Academic Health Science Centre. This unique partnership aims to improve the quality of life of patients and populations by taking new discoveries and translating them into new therapies as quickly as possible.

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