BibTex format
@article{Holden:2026,
author = {Holden, D},
journal = {mBio},
title = {MAP4Ks drive cell death in response to Salmonella SpvB-induced actin depolymerisation},
year = {2026}
}
RIS format (EndNote, RefMan)
TY - JOUR
AB - Many pathogens target the host actin cytoskeleton through the delivery of actin depolymerizing toxins, including mono-ADP-ribosyltransferases (mART), ultimately triggering host cell death. Despite the importance of mARTs in pathogen virulence, it remains unclear whether actin ribosylation is required for mART-dependent cell death, and how actin depolymerization leads to cell death. Using the non-typhoidal Salmonella enterica Typhimurium-encoded mART, SpvB, we report that cell death is induced exclusively through ribosylation of actin. We found cell death to be morphologically and mechanistically distinct from apoptosis as well as any previously reported mode of cell death. Instead, our data identify the Hippo signaling MAP4Ks as the essential host cell sensors of actin depolymerization signaling through JNK to facilitate vacuolization and host cell death. Cell death following treatment of cells with the actin depolymerizing agent latrunculin A followed the same pathway, identifying a conserved mechanism of cell death. Therefore, we identify MAP4K family members as key regulators of an atypical caspase-independent cell death induced by actin depolymerization, building on our understanding of host-cell death signaling and mechanisms of bacterial virulence
AU - Holden,D
PY - 2026///
SN - 2161-2129
TI - MAP4Ks drive cell death in response to Salmonella SpvB-induced actin depolymerisation
T2 - mBio
ER -