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• Journal article
  Demestre M, Boutelle M, Fillenz M, 1997,
  , JOURNAL OF PHYSIOLOGY-LONDON, Vol: 499, Pages: 825-832, ISSN: 0022-3751
  • Cite
  • Citations: 76
• Journal article
  Lowry JP, Boutelle MG, Fillenz M, 1997,
  , JOURNAL OF NEUROSCIENCE METHODS, Vol: 71, Pages: 177-182, ISSN: 0165-0270
  • Cite
  • Citations: 70
• Journal article
  Miele M, Boutelle MG, Fillenz M, 1996,
  , JOURNAL OF PHYSIOLOGY-LONDON, Vol: 497, Pages: 745-751, ISSN: 0022-3751
  • Cite
  • Citations: 68
• Journal article
  Fray AE, Forsyth RJ, Boutelle MG, Fillenz Met al., 1996,
  , JOURNAL OF PHYSIOLOGY-LONDON, Vol: 496, Pages: 49-57, ISSN: 0022-3751
  • Cite
  • Citations: 113
• Journal article
  Lowry JP, Boutelle MG, ONeill RD, Fillenz Met al., 1996,
  , ANALYST, Vol: 121, Pages: 761-766, ISSN: 0003-2654
  • Cite
  • Citations: 50
• Journal article
  Miele M, Berners M, Boutelle MG, Kusakabe H, Fillenz Met al., 1996,
  , BRAIN RESEARCH, Vol: 707, Pages: 131-133, ISSN: 0006-8993
  • Cite
  • Citations: 62
• Conference paper
  Forsyth R, Fray A, Boutelle M, Fillenz M, Middleditchc C, Burchell Aet al., 1996,
  , Pages: 360-370, ISSN: 0378-5866

  The present paper examines the possible role of astrocytes in the delivery of glycogen-derived glucose for neuronal metabolism. Such a process would require astrocytic expression of glucose-6-phosphatase. The degree and significance of brain expression of glucose-6-phosphatase (EC 3.1.3.9) has been a subject of controversy. Published immunohistochemical data are consistent with expression of glucose-6-phosphatase by astrocytes, both in vivo and in vitro. In this paper additional confirmation of the expression of glucose-6-phosphatase mRNA in rat brain is presented. Although cultured astrocytes demonstrate glucose-6-phosphatase activity in vitro under assay conditions, there is very limited in vitro evidence that this activity confers a glucose-export capacity on astrocytes. Under most conditions in vitro, lactate export predominates, however this may relate to aspects of the in vitro phenotype. Data relating to astrocytic glucose and lactate export are considered in the context of hypotheses of trafficking by astrocytes of substrates for neuronal metabolism, hypotheses that imply and require compartmentation of these substances, in contrast with current formulations of glucose transport into and within brain that imply no glucose compartmentation. Microdialysis studies of the properties of the brain extracellular fluid (ECF) glucose pool in the freely moving rat were performed seeking evidence of glucose compartmentation. Results of these studies do imply compartmentalisation of brain glucose, and are consistent with a model envisaging the majority of glucose reaching the neuron via the astrocytic intracellular space and the ECF. In addition, such studies provide evidence that rises in ECF glucose concentration are not the direct result of local recruitment of cerebral blood flow, but suggest the influence of intermediate, astrocyte-based mechanisms. Astrocytic glucose-6-phosphatase may permit astrocytes to modulate the transastrocytic flux of glucose to adjacent ne

  • Abstract
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  • Citations: 65
• Journal article
  Boutelle MG, Fillenz M, 1996,

  Clinical microdialysis: The role of on-line measurement and quantitative microdialysis

  , CLINICAL ASPECTS OF MICRODIALYSIS, Vol: 67, Pages: 13-20, ISSN: 0065-1419
  • Cite
  • Citations: 29
• Journal article
  WHEELER D, BOUTELLE MG, FILLENZ M, 1995,
  , NEUROSCIENCE, Vol: 65, Pages: 767-774, ISSN: 0306-4522
  • Cite
  • Citations: 65
• Journal article
  VAHABZADEH A, BOUTELLE MG, FILLENZ M, 1995,
  , EUROPEAN JOURNAL OF NEUROSCIENCE, Vol: 7, Pages: 175-179, ISSN: 0953-816X
  • Cite
  • Citations: 20

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