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• Journal article
  Sansuk S, Bitziou E, Joseph MB, Covington JA, Boutelle MG, Unwin PR, Macpherson JVet al., 2013,
  , ANALYTICAL CHEMISTRY, Vol: 85, Pages: 163-169, ISSN: 0003-2700
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  • Citations: 103
• Journal article
  Rogers ML, Boutelle MG, 2013,
  , ANNUAL REVIEW OF ANALYTICAL CHEMISTRY, VOL 6, Vol: 6, Pages: 427-453, ISSN: 1936-1327
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  • Citations: 38
• Journal article
  Corcoles EP, Boutelle MG, Deeba S, Hanna GB, Darzi Aet al., 2012,
  , 2012 International Conference on Biomedical Engineering Icobe 2012, Pages: 60-62

  The intestinal tract is one of the main organs that, after hemorrhage or shock, appears to be involved in an ischemic/reperfusion injury. Metabolic substances, such as glucose and lactate are useful measurements for the monitoring of intestinal ischemia, since this provokes variation of intracellular biochemical markers. In order to identify the ischemic/reperfusion mechanism adequately, physiological monitoring of the bowel under a different stress condition is required. Biomarkers were monitored during hypoxic conditions induced in a swine model to investigate the effect of this physiological variable on metabolic rates. Results showed that hypoxia could have different effects on bowel dialysate metabolites levels depending on tissue capabilities. © 2012 IEEE.

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  • Citations: 2
• Journal article
  Corcoles EP, Deeba S, Hanna GB, Boutelle MG, Darzi Aet al., 2011,
  , Proceedings International Conference on Instrumentation Communication Information Technology and Biomedical Engineering 2011 Icici Bme 2011, Pages: 361-365

  Microdialysis is a sampling technique based on the passive diffusion of the molecules through a small segment of cylindrical hollow fiber membrane implanted within the tissue of study. Calibration of the microdialysis probe and the parameters that affect this calibration are essential, since recovery factors are never 100%. In vitro calibration methods are typically used to compare the concentration of the outlet with the concentration of the medium. In vivo quantification methods of microdialysis data monitoring depends on active and passive tissue effects, complicating the calibration methods further. In vitro and in vivo microdialysis calibration methods were performed in gastrointestinal tissue of animal models and intensive care patients. Results showed that the discrepancy between in vitro and in vivo calibration method is minimal. © 2011 IEEE.

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  • Citations: 1
• Journal article
  Corcoles EP, Deeba S, Damji S, Hanna GB, Boutelle MG, Cheshire N, Stotz M, Darzi Aet al., 2011,

  Rapid sampling microdialysis monitorign of post aortic repair intestinal ischemia

  , JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, Vol: 26, Pages: 192-193, ISSN: 0815-9319
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• Journal article
  Damji S, Hamaoui K, Chang Y-M, Boutelle M, Deeba S, Hanna G, Taube D, Darzi A, Papalois Vet al., 2011,

  ORGAN VIABILITY ASSESSMENT IN THE PRESERVATION PERIOD UTILISING RAPID SAMPLING MICRODIALYSIS

  , TRANSPLANT INTERNATIONAL, Vol: 24, Pages: 197-197, ISSN: 0934-0874
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• Journal article
  Corcoles EP, Deeba S, Hanna GB, Paraskeva P, Boutelle MG, Darzi Aet al., 2011,
  , ANALYTICAL METHODS, Vol: 3, Pages: 2010-2016, ISSN: 1759-9660
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  • Citations: 5
• Journal article
  Damji S, Hamaoui K, Bullock N, Boutelle M, Agnes L, Rogers M, Gowers S, Hanna G, Darzi A, Papalois Vet al., 2011,

  ONLINE RAPID SAMPLING MICRODIALYSIS (rsMD) FOR VIABILITY ASSESSMENT, COMPARING STATIC COLD STORAGE VERSUS HYPOTHERMIC MACHINE PERFUSION IN MARGINAL ALLOGRAFTS

  , TRANSPLANT INTERNATIONAL, Vol: 24, Pages: 350-351, ISSN: 0934-0874
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• Journal article
  Patel BA, Rogers M, Wieder T, O'Hare D, Boutelle MGet al., 2011,
  , BIOSENSORS & BIOELECTRONICS, Vol: 26, Pages: 2890-2896, ISSN: 0956-5663
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  • Citations: 51
• Journal article
  Corcoles EP, Deeb S, Hanna G, Boutelle MG, Darzi Aet al., 2011,
  , Jurnal Teknologi Sciences and Engineering, Vol: 54, Pages: 47-59, ISSN: 0127-9696

  Intestinal ischaemia or poor perfusion of the gastrointestinal tract is a major cause of post-operative mortality in abdominal surgery. Currently diagnosis of ischaemia relies only on clinical symptoms. Thus, monitoring bowel metabolism as an early marker of intestinal ischaemia is necessary. Human bowel microdialysis has been used in the past to study the metabolism of ichaemia collecting dialysate samples from the peritoneal cavity every 60 minutes. These sampling times carry a long delay for the detection of the typically rapid ischaemic event. We have previously developed a successful biosensor system to monitor neurochemicals in the human brain during surgery and in the intensive care unit The method consists of a flow injection analysis (FIA) system coupled to an enzyme based amperometric detector. The rapid sampling microdialysis monitoring system analysed electrochemically the dialysate glucose and lactate at high time resolution (typically 30 second sampling). Adaptation of the analytical assay system for on-line microdialysis monitoring of human bowel was performed and validated for in vivo procedures. Optimum membranes loading ratios were found to be 1:0.5 GOx:HRP and 2:0.5 LOx:HRP. The ischemic range was found to be 15μM-400μM, 40μM-6mM for glucose and lactate, respectively. The calibration method for these monitorings was concluded with a range from 250 μM to 6 mM. © Universiti Teknologi Malaysia.

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