Notable Recent Publications

These are some recent publications which give a flavour of the research from the Barclay lab. For a complete list of publications, please see below.

Jason S. Long, Efstathios S. Giotis, Olivier Moncorgé, Rebecca Frise, Bhakti Mistry, Joe James, Mireille Morisson, Munir Iqbal, Alain Vignal, Michael A. Skinner & Wendy S. Barclay

This paper identified a key factor that explained why the polymerases from avian influenza viruses are restricted in humans.  For more, please see the associated .

See our latest ANP32 papers here: ,, .

Daniel H. Goldhill, Aartjan J. W. te Velthuis, Robert A. Fletcher, Pinky Langat, Maria Zambon, Angie Lackenby & Wendy S. Barclay

This paper showed how influenza could evolve resistance to favipiravir, an antiviral that may be used to treat influenza. The residue that mutated to give resistance was highly conserved suggesting that the mechanism of resistance may be applicable to other RNA viruses.

Hui Li*, Konrad C. Bradley*, Jason S. Long, Rebecca Frise, Jonathan W. Ashcroft, Lorian C. Hartgroves, Holly Shelton, Spyridon Makris, Cecilia Johansson, Bin Cao & Wendy S. Barclay

Why do avian influenza viruses like H5N1 cause such severe disease in humans? This paper demonstrated that H5N1 viruses replicate better than human viruses in myeloid cells from mice leading to a cytokine storm and more severe disease.

Citation

BibTex format

@article{Brookes:2011:jac/dkq486,
author = {Brookes, DW and Miah, S and Lackenby, A and Hartgroves, L and Barclay, WS},
doi = {jac/dkq486},
journal = {JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY},
pages = {466--470},
title = {Pandemic H1N1 2009 influenza virus with the H275Y oseltamivir resistance neuraminidase mutation shows a small compromise in enzyme activity and viral fitness},
url = {http://dx.doi.org/10.1093/jac/dkq486},
volume = {66},
year = {2011}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AU  - Brookes,DW
AU  - Miah,S
AU  - Lackenby,A
AU  - Hartgroves,L
AU  - Barclay,WS
DO  - jac/dkq486
EP  - 470
PY  - 2011///
SN  - 0305-7453
SP  - 466
TI  - Pandemic H1N1 2009 influenza virus with the H275Y oseltamivir resistance neuraminidase mutation shows a small compromise in enzyme activity and viral fitness
T2  - JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
UR  - http://dx.doi.org/10.1093/jac/dkq486
VL  - 66
ER  -
Download

Contact us

For any enquiries related to this group, please contact:

Professor Wendy Barclay
Chair in Influenza Virology 
+44 (020) 7594 5035
w.barclay@imperial.ac.uk